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                            November 21, 2023

       David Chang
       President and Chief Executive Officer
       Allogene Therapeutics, Inc.
       210 East Grand Avenue
       South San Francisco, California 94080

                                                        Re: Allogene
Therapeutics, Inc.
                                                            Form 10-K for
Fiscal Year Ended December 31, 2022
                                                            Filed February 28,
2023
                                                            File No. 001-38693

       Dear David Chang:

              We have limited our review of your filing to the financial
statements and related
       disclosures and have the following comments.

              Please respond to this letter within ten business days by
providing the requested
       information or advise us as soon as possible when you will respond. If
you do not believe a
       comment applies to your facts and circumstances, please tell us why in
your response.

                                                        After reviewing your
response to this letter, we may have additional comments.

       Form 10-K for Fiscal Year Ended December 31, 2022

       Management's Discussion and Analysis of Financial Condition and Results
of Operations
       Results of Operations
       Research and Development, page 85

   1.                                                   We note you reported
significant research and development expenses and that you have
                                                        multiple
programs/product candidates in varying stages of development and clinical
                                                        testing, and note that
you expect your research and development expenses to increase.
                                                        Please confirm that you
will revise future filings to provide more details about
                                                        your research and
development expenses for each period presented, including but not
                                                        limited to by
product/program, internal versus external, as well as by the nature of the
                                                        expenses. For example,
in discussing the specific reasons for significant changes
                                                        in research and
development expenses, quantify the change by each product candidate for
                                                        which significant
investments were made during the periods. Refer to Item 303(b) of
                                                        Regulation S-K. To the
extent that you do not track expenses by product candidate, please
                                                        disclose as such.
 David Chang
Allogene Therapeutics, Inc.
November 21, 2023
Page 2
Notes to Consolidated Financial Statements
6. Joint Venture and License Agreement with Allogene Overland Biopharm (CY)
Limited, page
111

2.       Please address the following as it relates to your Joint Venture and
License Agreement
         with Allogene Overland Biopharm (CY) Limited (Allogene Overland):

            Provide your analysis under ASC 606 supporting your determination
that the
          transaction price should not include the fair value of the Seed
Preferred Shares
          received from Allogene Overland, representing a 49% ownership
interest. As part of
          your response, address your consideration of Article 8.1 of the
License Agreement,
          which specifically states that upfront consideration for the license
included both the
          $40 million non-refundable payment and the Seed Preferred Shares
representing 49%
          of Allogene Overland.
           Tell us and revise your future filings to disclose the amount of the
transaction price
          allocated to each performance obligation.
           Provide your analysis under ASC 323 supporting the initial
measurement of your
          investment in Allogene Overland at zero. Address the following as
part of your
          response:
            o   Explain your consideration of ASC 323-10-30-2 in determining
the applicability
                of ASC 610-20 and whether the license transferred should be
measured based
                on its fair value.
            o   Explain whether you identified a basis difference between your
initial
                investment in Allogene Overland and your proportionate share of
the underlying
                net assets in Allogene Overland and your accounting treatment
for any such
                basis difference.
           Provide your analysis under ASC 810 supporting your determination
that you are not
          the primary beneficiary of Allogene Overland. As part of your
response, identify the
          activities of Allogene Overland that most significantly impact its
economic
          performance and explain how you determined that you do not have the
power to
          direct such activities and therefore do not hold a controlling
financial interest.To the
          extent that the power is shared among the variable interest holders,
clarify whether
          there is a tie-breaking mechanism in place with respect to key
decision making.
           Please confirm with us that in future filings you will expand to
provide all the
          required disclosures under ASC 810-10-50 Disclosure     Variable
Interest
FirstName LastNameDavid
          Entities, includingChang
                                but not limited to those required for
nonprimary beneficiary holder
Comapany of
          NameAllogene      Therapeutics,
             a variable interest  in a VIE Inc.
                                           under 50-4, as well as other
disclosures needed to
          fulfill
November 21,  2023thePage
                      principal
                           2 objectives under 50-2AA.
FirstName LastName
 David Chang
FirstName LastNameDavid
Allogene Therapeutics, Inc. Chang
Comapany 21,
November  NameAllogene
              2023        Therapeutics, Inc.
November
Page 3    21, 2023 Page 3
FirstName LastName
       In closing, we remind you that the company and its management are
responsible for the
accuracy and adequacy of their disclosures, notwithstanding any review,
comments, action or
absence of action by the staff.

       Please contact Li Xiao at 202-551-4391 or Angela Connell at 202-551-3426
with any
questions.



                                                          Sincerely,

                                                          Division of
Corporation Finance
                                                          Office of Life
Sciences