X0306 4 2020-08-06 0 0001609550 Inspire Medical Systems, Inc. INSP 0001737136 Herbert Timothy P. C/O INSPIRE MEDICAL SYSTEMS, INC. 5500 WAYZATA BLVD., SUITE 1600 GOLDEN VALLEY MN 55416 1 1 0 0 CEO and President Common Stock 2020-05-04 5 G 0 E 3600 0 D 11724 I By family trust Common Stock 2020-08-06 4 S 0 57583 105.16 D 225292 I By family trust Common Stock 2020-08-06 4 S 0 14770 106.68 D 210522 I By family trust Common Stock 2020-08-06 4 S 0 7205 107.40 D 203317 I By family trust Common Stock 2020-08-06 4 S 0 442 108.16 D 202875 I By family trust Common Stock 65845 D Common Stock 113138 I By GRAT Common Stock 350 I By daughter Shares held by the Timothy P. Herbert 2013 Family Irrevocable GST Trust U/A/D November 27, 2013. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $105.00 to $105.98. The reporting person undertakes to provide Inspire Medical Systems, Inc. (the "Company"), any security holder of the Company, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Shares held by the Margaret C. Herbert 2018 Family Irrevocable GST Trust. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $106.00 to $106.99. The reporting person undertakes to provide the Company, any security holder of the Company, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $107.00 to $107.99. The reporting person undertakes to provide the Company, any security holder of the Company, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $108.02 to $108.28. The reporting person undertakes to provide the Company, any security holder of the Company, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Includes 197 shares acquired under the Company's 2018 Employee Stock Purchase Plan since the date of the reporting person's last ownership report. All of the shares reported herein were previously reported as being directly held by the reporting person. Securities held by the Timothy P. Herbert 2018 Grantor Retained Annuity Trust, under agreement dated December 12, 2018. /s/ Richard Buchholz, Attorney-in-Fact for Timothy P. Herbert 2020-08-10