SCHEDULE 13G 0001274173 XXXXXXXX LIVE Common Stock 12/31/2025 0001736730 CAMP4 THERAPEUTICS CORP 13463J101 ONE KENDALL SQUARE BUILDING 1400 WEST, 3RD FLOOR CAMBRIDGE MA 02139 Rule 13d-1(b) JANUS HENDERSON GROUP PLC Y9 0 6307636 0 6307636 6307636 12.2 IA HC CAMP4 THERAPEUTICS CORP ONE KENDALL SQUARE, BUILDING 1400 WEST, 3RD FLOOR CAMBRIDGE, MA 02139 Janus Henderson Group plc 201 Bishopsgate EC2M 3AE, United Kingdom Y9 N HC JHIUS may be deemed to be the beneficial owner of 6,307,636 shares, as well as an additional 1,241,382 pre-funded warrants which cannot be exercised to the extent they result in ownership in excess of 9.99%. 12.2 0 6307636 0 6307636 Y N N The interest of one person, Janus Henderson Enterprise Fund, an investment company registered under the Investment Company Act of 1940, in ICU Medical Common Stock amounted to 1,230,753 shares or 5.0% N See Exihibit 99 N N/A N N/A N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Exhibit 24: Power of Attorney Exhibit 99: Item 7 JANUS HENDERSON GROUP PLC Kristin Mariani 01/08/2026