<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Qu Yu -->
          <cik>0002113252</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001736541</issuerCik>
      <issuerName>NIO Inc.</issuerName>
      <secFileNumber>001-38638</secFileNumber>
      <issuerAddress>
        <com:street1>Building 19, No. 1355</com:street1>
        <com:street2>Caobao Road, Minhang District</com:street2>
        <com:city>Shanghai</com:city>
        <com:stateOrCountry>F4</com:stateOrCountry>
        <com:zipCode>200233</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>86-21-69082018</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Yu Qu</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>American depositary shares (each representing one Class A ordinary share)</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>The Core Securities Company Limited</name>
        <address>
          <com:street1>Suite C, 20/F, Standard Chartered Bank</com:street1>
          <com:street2>Building 4-4A Des Voeux Road Central</com:street2>
          <com:city>Central</com:city>
          <com:stateOrCountry>K3</com:stateOrCountry>
          <com:zipCode>999077</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>122500</noOfUnitsSold>
      <aggregateMarketValue>518175.00</aggregateMarketValue>
      <noOfUnitsOutstanding>2357167022</noOfUnitsOutstanding>
      <approxSaleDate>09/01/2026</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>American depositary shares (each representing one Class A ordinary share)</securitiesClassTitle>
      <acquiredDate>09/01/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Vesting of restricted share units granted pursuant to the Issuer's share incentive plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>NIO Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>122500</amountOfSecuritiesAcquired>
      <paymentDate>09/01/2026</paymentDate>
      <natureOfPayment>Vesting of restricted share units</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Yu Qu</name>
        <address>
          <com:street1>Building 19, No. 1355</com:street1>
          <com:street2>Caobao Road, Minhang District</com:street2>
          <com:city>Shanghai</com:city>
          <com:stateOrCountry>F4</com:stateOrCountry>
          <com:zipCode>200233</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American depositary shares (each representing one Class A ordinary share) sold to cover tax only, as reported on June 1, 2026</securitiesClassTitle>
      <saleDate>06/08/2026</saleDate>
      <amountOfSecuritiesSold>100000</amountOfSecuritiesSold>
      <grossProceeds>551986.93</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The securities set forth herein are being sold pursuant to a non-discretionary sell-to-cover arrangement for the purpose of satisfying income tax liabilities incurred upon vesting of restricted share units only. The securities covered by this filing will be sold today or within three months from the date of this filing.</remarks>
    <noticeSignature>
      <noticeDate>09/01/2026</noticeDate>
      <signature>/s/ Eve Tang, Attorney-in-Fact for Yu Qu</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
