<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Zhou Xin -->
          <cik>0002109480</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001736541</issuerCik>
      <issuerName>NIO Inc.</issuerName>
      <secFileNumber>001-38638</secFileNumber>
      <issuerAddress>
        <com:street1>Building 19, No. 1355</com:street1>
        <com:street2>Caobao Road, Minhang District</com:street2>
        <com:city>Shanghai</com:city>
        <com:stateOrCountry>F4</com:stateOrCountry>
        <com:zipCode>200233</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>86-21-69082018</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Xin Zhou</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>American depositary shares (each representing one Class A ordinary share)</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>The Core Securities Company Limited</name>
        <address>
          <com:street1>Suite C, 20/F, Standard Chartered Bank</com:street1>
          <com:street2>Building 4-4A Des Voeux Road Central</com:street2>
          <com:city>Central</com:city>
          <com:stateOrCountry>K3</com:stateOrCountry>
          <com:zipCode>999077</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>100000</noOfUnitsSold>
      <aggregateMarketValue>560000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>2357167022</noOfUnitsOutstanding>
      <approxSaleDate>06/01/2026</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>American depositary shares (each representing one Class A ordinary share)</securitiesClassTitle>
      <acquiredDate>06/01/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Vesting of restricted share units granted pursuant to the Issuer's Share Incentive Plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>NIO Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>100000</amountOfSecuritiesAcquired>
      <paymentDate>06/01/2026</paymentDate>
      <natureOfPayment>Vesting of restricted share units</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>The securities set forth herein are being sold pursuant to a sell-to-cover arrangement for the purpose of satisfying income tax liabilities incurred upon vesting of restricted share units only. The securities covered by this filing will be sold today or within three months from the date of this filing.</remarks>
    <noticeSignature>
      <noticeDate>06/01/2026</noticeDate>
      <signature>/s/ Eve Tang, Attorney-in-Fact for Xin Zhou</signature>
    </noticeSignature>
  </formData>

</edgarSubmission>
