SCHEDULE 13G 0001799740 XXXXXXXX LIVE Ordinary shares, nominal value $0.00003881 per share 12/31/2023 0001735438 MeiraGTx Holdings plc G59665102 450 EAST 29TH STREET 15TH FLOOR NEW YORK NY 10016 Rule 13d-1(d) ADENA ESTATE INC. b D8 3266806.00 0.00 3266806.00 0.00 3266806.00 5.1 CO MeiraGTx Holdings plc 450 EAST 29TH STREET, 15TH FLOOR, NEW YORK, NEW YORK, 10016. Adena Estate Inc. PO Box 71, Craigmuir Chambers, Road Town, Tortola, British Virgin Islands, VG1110 British Virgin Islands Y 3,266,806 Ordinary Shares 5.14% 3,266,806 0 3,266,806 0 Y N Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. ADENA ESTATE INC. Mark Hamilton 02/08/2024