X0306 4 2020-07-20 0 0001735438 MeiraGTx Holdings plc MGTX 0001204362 SHENK THOMAS E 450 E. 29TH STREET, 14TH FLOOR NEW YORK NY 10016 1 0 0 0 Ordinary Shares 2020-07-20 4 S 0 6667 15.00 D 157476 I See Footnote The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 27, 2019. The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.025, inclusive. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price. Represents securities held of record by Double Epiphany, LLC ("Double Epiphany"). The reporting person is a managing member of Double Epiphany and has full voting and investment power with respect to the shares held by Double Epiphany. The reporting person disclaims beneficial ownership of such shares except to the extent of any pecuniary interest therein. /s/ Richard Giroux, Attorney-in-Fact for Thomas E. Shenk 2020-07-22