X0306 4 2020-05-12 0 0001735438 MeiraGTx Holdings plc MGTX 0001216955 MARCUS JOEL S 450 E. 29TH STREET, 14TH FLOOR NEW YORK NY 10016 1 0 0 0 Ordinary Shares 2020-05-12 4 S 0 4900 15.77 D 75022 I By Third Amended and Restated Joel and Barbara Marcus Family Trust Ordinary Shares 2020-05-12 4 S 0 22 15.812 D 75000 I By Third Amended and Restated Joel and Barbara Marcus Family Trust Ordinary Shares 1982726 I See Footnote Represents securities held of record by Alexandria Venture Investments, LLC ("Alexandria"). Alexandria Real Estate Equities, Inc. is the managing member of Alexandria. Each of Alexandria and Alexandria Real Estate Equities, Inc. has shared voting and investment power with respect to the shares owned by Alexandria. The reporting person is the Executive Chairman of Alexandria Real Estate Equities, Inc. and may therefore be deemed to have voting and investment power with respect to the shares owned by Alexandria. Each of the reporting person and Alexandria Real Estate Equities, Inc. disclaims beneficial ownership of such shares except to the extent of any pecuniary interest therein. /s/ Richard Giroux, Attorney-in-Fact for Joel S. Marcus 2020-05-14