X0306 4 2020-05-11 0 0001735438 MeiraGTx Holdings plc MGTX 0001204362 SHENK THOMAS E 450 E. 29TH STREET, 14TH FLOOR NEW YORK NY 10016 1 0 0 0 Ordinary Shares 2020-05-11 4 S 0 2184 15.00 D 164143 I See Footnote The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 27, 2019. Represents securities held of record by Double Epiphany, LLC ("Double Epiphany"). The reporting person is a managing member of Double Epiphany and has full voting and investment power with respect to the shares held by Double Epiphany. The reporting person disclaims beneficial ownership of such shares except to the extent of any pecuniary interest therein. /s/ Richard Giroux, Attorney-in-Fact for Thomas E. Shenk 2020-05-13