X0306 4 2020-04-07 0 0001659323 Iterum Therapeutics plc ITRM 0001734389 Chin Mark C/O ITERUM THERAPEUTICS PLC, BLK 2 FL. 3, HARCOURT CENTRE, HARCOURT ST. DUBLIN L2 2 IRELAND 1 0 0 0 Ordinary Shares 2020-04-07 5 J 0 E 1089903 D 0 I By Arix Bioscience Holdings Ltd. Ordinary Shares 6154 D 6.500% Exchangeable Senior Subordinated Note due 2025 2020-04-07 5 J 0 E 1900000.00 D 2025-01-31 Ordinary Shares 1900000 0 I By Arix Bioscience Holdings Ltd. On April 7, 2020, the reporting person resigned as an investment director for Arix Bioscience plc, which is the sole owner and parent of Arix Bioscience Holdings Ltd., which holds these securities. As a result of his resignation, the reporting person no longer has any voting power over these securities and therefore has ceased to beneficially own such securities. Arix Bioscience Holdings Ltd. continues to hold these securities. /s/ Mark Chin 2020-04-09