X0306 4 2022-04-01 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001733883 JOHNSON DAVID LEE C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BLVD. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Commercial Officer Common Stock 2022-04-01 4 M 0 4375 A 49937 D Common Stock 2022-04-01 4 F 0 1513 35.91 D 48424 D Restricted Stock Units 2022-04-01 4 M 0 4375 0.00 D Common Stock 4375 0 D Each Restricted Stock Unit ("RSU") represents the right to receive one share of the Issuer's Common Stock. Represents the number of shares of the Issuer's Common Stock withheld to satisfy the Reporting Person's tax obligations in connection with the vesting of 4,375 shares of Common Stock underlying the Reporting Person's RSUs. The shares of Common Stock underlying the RSUs vested with respect to 1/4th of the underlying shares on April 1, 2019, and with respect to 1/6th of the remaining underlying shares on a semi-annual basis thereafter through April 1, 2022. /s/ Miguel Carrillo, Attorney-in-Fact 2022-04-05