SCHEDULE 13G/A 0000904454-19-000355 0001732811 XXXXXXXX LIVE 2 Common Stock, no par value 12/31/2024 0001755237 Cyclerion Therapeutics, Inc. 23255M105 301 BINNEY STREET CAMBRIDGE MA 02142 Rule 13d-1(c) MFN Partners, LP DE 0 0 0 0 0 N 0 PN MFN Partners GP, LLC DE 0 0 0 0 0 N 0 OO MFN Partners Management, LP DE 0 0 0 0 0 N 0 IA PN MFN Partners Management, LLC DE 0 0 0 0 0 N 0 OO Michael F. DeMichele X1 0 0 0 0 0 N 0 IN Farhad Nanji Z4 0 0 0 0 0 N 0 IN Cyclerion Therapeutics, Inc. 301 Binney Street, Cambridge, MA 02142 This Amendment No. 2 to Schedule 13G is filed by (i) MFN Partners, LP (the "Partnership"); (ii) MFN Partners GP, LLC ("MFN GP"), as the general partner of the Partnership; (iii) MFN Partners Management, LP ("MFN Management"), as the investment adviser to the Partnership; (iv) MFN Partners Management, LLC ("MFN LLC"), as the general partner of MFN Management; (v) Michael F. DeMichele, as a managing member of MFN GP and of MFN LLC; and (vi) Farhad Nanji, as a managing member of MFN GP and of MFN LLC (each, a "Reporting Person" and collectively, the "Reporting Persons"). Reference is hereby made to the Schedule 13G filed with the Securities and Exchange Commission by the Reporting Persons with respect to the Common Stock of the Issuer on February 12, 2021 and Amendment No. 1 thereto filed on February 2, 2022 (as so amended, the "Schedule 13G"). Terms defined in the Schedule 13G are used herein as so defined. The shares previously reported in the Schedule 13G were directly held by the Partnership and each of the Reporting Persons disclaims beneficial ownership of such shares except to the extent of its or his pecuniary interest therein. The items included in this Amendment No. 2 are hereby amended and restated. c/o MFN Partners Management, LP, 222 Berkeley Street, 13th Floor, Boston, MA 02116 The Partnership is a Delaware limited partnership. MFN GP is a Delaware limited liability company. MFN Management is a Delaware limited partnership. MFN LLC is a Delaware limited liability company. Michael F. DeMichele is a citizen of the United States and Farhad Nanji is citizen of Canada. N The information required by this item is set forth in the cover pages to this Schedule 13G/A and is incorporated herein by reference. The information required by this item is set forth in the cover pages to this Schedule 13G/A and is incorporated herein by reference. The information required by this item is set forth in the cover pages to this Schedule 13G/A and is incorporated herein by reference. The information required by this item is set forth in the cover pages to this Schedule 13G/A and is incorporated herein by reference. The information required by this item is set forth in the cover pages to this Schedule 13G/A and is incorporated herein by reference. The information required by this item is set forth in the cover pages to this Schedule 13G/A and is incorporated herein by reference. N Y N N N N N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. MFN Partners, LP /s/ Jonathan Reisman 02/12/2025 MFN Partners GP, LLC /s/ Jonathan Reisman 02/12/2025 MFN Partners Management, LP /s/ Jonathan Reisman 02/12/2025 MFN Partners Management, LLC /s/ Jonathan Reisman 02/12/2025 Michael F. DeMichele /s/ Michael F. DeMichele 02/12/2025 Farhad Nanji /s/ Farhad Nanji 02/12/2025