<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144/A</submissionType>
    <previousAccessionNumber>0001974078-25-000417</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001732239</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001352010</issuerCik>
      <issuerName>EPAM Systems, Inc.</issuerName>
      <secFileNumber>001-35418</secFileNumber>
      <issuerAddress>
        <com:street1>41 UNIVERSITY DRIVE</com:street1>
        <com:street2>SUITE 202</com:street2>
        <com:city>NEWTOWN</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>18940</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(267) 759-9000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Dvorkin Viktar</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Raymond James &amp; Associates</name>
        <address>
          <com:street1>880 Carillon Parkway</com:street1>
          <com:city>St. Petersburg</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33716</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2500</noOfUnitsSold>
      <aggregateMarketValue>454497.20</aggregateMarketValue>
      <noOfUnitsOutstanding>55242618</noOfUnitsOutstanding>
      <approxSaleDate>11/13/2025</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/17/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Services rendered</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>5195</amountOfSecuritiesAcquired>
      <paymentDate>05/17/2024</paymentDate>
      <natureOfPayment>Option exercise</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Aggregate Market Value updated </remarks>
    <noticeSignature>
      <noticeDate>11/13/2025</noticeDate>
      <signature>Maressia Rooks-Bailey, as duly authorized representative of Raymond James &amp; Associates, Inc., as attorney-in-fact for Viktar Dvorkin</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
