X0306 4 2023-03-03 0 0001704292 Zai Lab Ltd ZLAB 0001731790 Du Ying C/O ZAI LAB LIMITED 314 MAIN STREET, 4TH FLOOR, SUITE 100 CAMBRIDGE MA 02142 1 1 0 0 Chairperson & CEO American Depositary Shares 2023-03-03 4 G 0 21564 0.00 D 837411 D American Depositary Shares 2023-03-03 4 G 0 21564 0.00 D 815847 D American Depositary Shares 2023-03-06 4 M 0 300000 0.00 A 1115847 D American Depositary Shares 2023-03-06 4 F 0 120906 0.00 D 994941 D American Depositary Shares 2023-03-06 4 G 0 426 0.00 D 994515 D American Depositary Shares 2023-03-06 4 G 0 426 0.00 D 994089 D Stock Options (Right to Buy) 0.60 2023-03-06 4 M 0 300000 0.00 D 2025-10-22 American Depositary Shares 300000 589165 D Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs. This transaction represents a bona fide charitable contribution as a gift. This transaction represents a bona fide charitable contribution as a gift. The reported transaction was effected pursuant to a sale plan adopted by the Reporting Person, dated 12/13/2022, that expires on 12/20/2023 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1034. This transaction represents the disposition of shares to cover taxes. This transaction represents a bona fide gift of securities by the reporting person to an UTMA account for the benefit of the reporting person's adult child. This transaction represents a bona fide gift of securities by the reporting person to the reporting person's adult child. The Stock Options fully vested as of October 22, 2020. /s/ Bruce Blefeld, Attorney-in-Fact 2023-03-07