X0306 5 2021-12-31 0 0 0 0001704292 Zai Lab Ltd ZLAB 0001731790 Du Ying C/O ZAI LAB LIMITED 314 MAIN STREET, 4TH FLOOR, SUITE 100 CAMBRIDGE MA 02142 1 1 0 0 Chairperson & CEO American Depositary Shares 2021-12-31 5 G 0 8000 0.00 D 1000653 D Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 5, we are reporting this in terms of ADSs. Due to inadvertent administrative error, this transaction is being filed late. This transaction represents a bona fide charitable contribution as a gift to a donor advisory fund. /s/ Bruce A. Blefeld, Attorney-in-Fact 2022-12-09