X0306 4 2022-01-05 0 0001704292 Zai Lab Ltd ZLAB 0001731790 Du Ying C/O ZAI LAB LIMITED 314 MAIN STREET, 4TH FLOOR, SUITE 100 CAMBRIDGE MA 02142 1 1 0 0 Chairperson & CEO American Depositary Shares 2022-01-05 5 G 0 E 475 0.00 D 1003578 D American Depositary Shares 2022-01-05 5 G 0 E 475 0.00 D 1003103 D American Depositary Shares 2022-01-05 5 G 0 E 475 0.00 A 475 I Custodian of UTMA for child American Depositary Shares 2022-01-05 5 G 0 E 14300 0.00 D 988803 D American Depositary Shares 2022-01-28 5 G 0 E 9000 0.00 D 979803 D American Depositary Shares 2022-04-01 4 F 0 828 45.47 D 978975 D American Depositary Shares 2022-06-21 5 G 0 E 120000 0.00 D 858975 D Each American Depositary Share (ADS) represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs. Due to inadvertent administrative error, this transaction is being filed late. This transaction represents a bona fide gift of securities by the reporting person to an UTMA account for the benefit of the reporting person's adult child. This transaction represents a bona fide gift of securities by the reporting person to an UTMA account for the benefit of the reporting person's minor child. Because such shares were gifted to UTMA custodial accounts for the benefit of the reporting person's child and for which the reporting person is the custodian, the reporting person may be deemed to have acquired indirect beneficial ownership of such shares upon gifting them to the custodial account. This transaction represents the transfer of shares held by the reporting person to a trust established for the benefit of the reporting person's children. This transaction represents a bona fide charitable contribution as a gift to a donor advisory fund. This transaction represents the disposition of shares to cover taxes. /s/ Bruce Blefeld, Attorney-in-Fact 2022-12-09