<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2020-06-04</periodOfReport>

    <issuer>
        <issuerCik>0001576280</issuerCik>
        <issuerName>Guardant Health, Inc.</issuerName>
        <issuerTradingSymbol>GH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001782391</rptOwnerCik>
            <rptOwnerName>SVF Bluebird (Cayman) Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WALKERS CORP LTD CAYMAN CORP CENTRE</rptOwnerStreet1>
            <rptOwnerStreet2>27 HOSPITAL ROAD GEORGE TOWN</rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-9008</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001755143</rptOwnerCik>
            <rptOwnerName>SOFTBANK VISION FUND (AIV M1) L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>251 LITTLE FALLS DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>WILMINGTON</rptOwnerCity>
            <rptOwnerState>DE</rptOwnerState>
            <rptOwnerZipCode>19808</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001731509</rptOwnerCik>
            <rptOwnerName>SB INVESTMENT ADVISERS (UK) LTD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>69 GROSVENOR STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LONDON</rptOwnerCity>
            <rptOwnerState>X0</rptOwnerState>
            <rptOwnerZipCode>W1K 3JP</rptOwnerZipCode>
            <rptOwnerStateDescription>UNITED KINGDOM</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001782460</rptOwnerCik>
            <rptOwnerName>SVF Enterprise (Cayman) Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WALKERS CORP LTD CAYMAN CORP CENTRE</rptOwnerStreet1>
            <rptOwnerStreet2>27 HOSPITAL ROAD GEORGE TOWN</rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-9008</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001782338</rptOwnerCik>
            <rptOwnerName>SVF Endurance (Cayman) Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WALKERS CORP LTD CAYMAN CORP CENTRE</rptOwnerStreet1>
            <rptOwnerStreet2>27 HOSPITAL ROAD GEORGE TOWN</rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-9008</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-06-04</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>7750000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>83.16</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>15200460</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-06-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1162500</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>83.16</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14037960</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">SVF Bluebird (Cayman) Limited is a subsidiary of SVF Enterprise (Cayman) Limited and FPP (Cayman) Limited. SVF Enterprise (Cayman) Limited is a subsidiary of SVF Endurance (Cayman) Limited and FPP (Cayman) Limited. FPP (Cayman) Limited, pursuant to its holding shares in each entity, serves as a share trustee for each entity. SVF Endurance (Cayman) Limited is a wholly owned subsidiary of SoftBank Vision Fund (AIV MI) L.P. SB Investment Advisers (UK) Limited has been appointed as alternative investment fund manager or AIFM of SoftBank Vision Fund (AIV MI) L.P., and is exclusively responsible for managing SoftBank Vision Fund (AIV MI) L.P. in accordance with the Alternative Investment Fund Managers Directive and is authorized and regulated by the UK Financial Conduct Authority accordingly. (continued to Fn. 2)</footnote>
        <footnote id="F2">(Continued from Fn.1) As AIFM of SoftBank Vision Fund (AIV MI) L.P., SB Investment Advisers (UK) Limited is exclusively responsible for making all decisions related to the acquisition, structuring, financing and disposal of SoftBank Vision Fund (AIV MI) L.P.'s Investments. Each Reporting Person disclaims beneficial ownership of such shares except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission that any reporting person is the beneficial owner of such shares for purposes of the Securities Exchange Act of 1934 or for any other purpose.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Karen Ellerbe Name: Karen Ellerbe Title: Director Entity: SVF Bluebird (Cayman) Limited</signatureName>
        <signatureDate>2020-06-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Brian Wheeler Name: Brian Wheeler Title: General Counsel Entity: SB Investment Advisers (UK) Limited, Manager of  SoftBank Vision Fund (AIV MI) L.P.</signatureName>
        <signatureDate>2020-06-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>s/ Brian Wheeler Name: Brian Wheeler Title: General Counsel Entity: SB Investment Advisers (UK) Limited</signatureName>
        <signatureDate>2020-06-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Karen Ellerbe Name: Karen Ellerbe Title: Director Entity: SVF Enterprise (Cayman) Limited</signatureName>
        <signatureDate>2020-06-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Karen Ellerbe Name: Karen Ellerbe Title: Director Entity: SVF Endurance (Cayman) Limited</signatureName>
        <signatureDate>2020-06-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
