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Summary of Significant Accounting Policies - Property and Equipment (Details) - USD ($)
3 Months Ended 12 Months Ended
Apr. 01, 2019
Dec. 31, 2018
Dec. 31, 2019
Sep. 30, 2018
Sep. 30, 2017
Property, Plant and Equipment          
Fixed asset impairment   $ 0 $ 4,102,000 $ 0 $ 0
Decrease in depreciation expense   $ (645,000) $ (4,611,000) $ (1,709,000) $ (1,009,000)
Increase in basic and diluted net loss per ordinary share (usd per share)   $ (0.52) $ (2.88) $ (1.42) $ (1.43)
Change in fixed asset assumptions          
Property, Plant and Equipment          
Decrease in depreciation expense     $ 300,000    
Increase in basic and diluted net loss per ordinary share (usd per share)     $ 0.01    
Office equipment          
Property, Plant and Equipment          
Property, plant and equipment useful life     3 years    
Lab equipment | Minimum          
Property, Plant and Equipment          
Property, plant and equipment useful life 5 years   5 years    
Lab equipment | Maximum          
Property, Plant and Equipment          
Property, plant and equipment useful life 10 years   10 years    
Furniture and fixtures          
Property, Plant and Equipment          
Property, plant and equipment useful life     5 years