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Share Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2019
Share-based Payment Arrangement [Abstract]  
Schedule of Stock Options Valuation Assumptions
The assumptions (see Note 2) used in the Black-Scholes option pricing model to determine the fair value of the share options granted to employees and directors during the year ended December 31, 2019 and 2018 were as follows:

 
Year Ended December 31,
 
Three Months Ended December 31,
 
Year Ended September 30,
 
2019
 
2018
 
2018
 
2017
Expected option life (years)
5.27 to 6.08
 
6.08
 
6.08
 
6.08
Risk-free interest rate
1.39% to 2.66%
 
2.70% to 3.09%
 
2.61% to 3.00%
 
1.91% to 2.05%
Expected volatility
72.30% to 76.22%
 
69.52% to 71.26%
 
68.15% to 72.99%
 
68.61% to 68.93%
Expected dividend yield
—%
 
—%
 
—%
 
—%
Stock Option Rollforward
The table below summarizes activity for the year ended December 31, 2019.

 
 
Number of
Options
 
Weighted-
Average
Exercise
Price
 
Weighted-
Average
Remaining
Contractual
Term
(Years)
 
Aggregate
Intrinsic
Value
Outstanding as of December 31, 2018
 
3,711,274

 
$
19.25

 
9.47

 
$
51,464

Granted
 
2,438,145

 
15.22

 
—

 
—

Exercised
 
(11,724
)
 
3.94

 
—

 
$
198

Forfeited
 
(201,456
)
 
19.72

 
—

 
—

Outstanding as of December 31, 2019
 
5,936,239

 
$
17.71

 
9.02

 
$
11,873

Exercisable as of December 31, 2019
 
1,466,625

 
$
16.34

 
8.63

 
$
6,124

Vested and expected to vest as of December 31, 2019
 
5,936,239

 
$
17.71

 
9.02

 
$
11,873
Schedule of Restricted Stock Valuation Assumptions
The assumptions (Note 2) used in the OPM to determine the fair value of the ordinary shares for the following dates are as follows:
 
 
March 2, 
2016
 
April 26, 
2017
 
September 25, 
2017
 
March 31, 2018
 
May 31, 2018
Expected term
 
2.8 years

 
1.2 years

 
0.8 years

 
1.8 years

 
1.8 years

Risk-free interest rate
 
1.0
%
 
1.0
%
 
1.3
%
 
2.1
%
 
2.1
%
Expected volatility
 
73.2
%
 
76.6
%
 
71.0
%
 
71
%
 
71
%
Expected dividend yield
 
0.0
%
 
0.0
%
 
0.0
%
 
0.0
%
 
0.0
%
Schedule of Nonvested Share Activity
A summary of the changes in the Company’s restricted ordinary shares during the years ended December 31, 2019 and 2018 are as follows and reflect the conversion of ordinary shares in the current and previous years.
 
 
Number of
restricted
shares
 
Weighted average 
grant date 
fair value
Unvested and outstanding at December 31, 2018
 
708,834

 
$
4.10

Granted
 
0

 
0.00

Vested
 
(389,755
)
 
4.31

Forfeited
 
(4,335
)
 
4.43

Unvested and outstanding at December 31, 2019
 
314,744

 
9.05

During the year ended December 31, 2019, the Company granted 500,000 RSUs under the 2018 Plan. The following is a summary of RSU activity for the 2018 Plan for the years ended December 31, 2019 and 2018, respectively:
    
 
 
Number of
restricted
units
 
Weighted average
grant date
fair value
Unvested and outstanding at December 31, 2018
 
—

 
$
—

       Granted
 
500,000

 
12.09

       Vested
 
—

 
—

       Forfeited
 
—

 
—

Unvested and outstanding at December 31, 2019
 
500,000

 
12.09
Schedule of Allocated Share Based Compensation
Share-based compensation expense recorded as research and development and general and administrative expenses is as follows (in thousands):
 
 
Year Ended December 31,
 
Three Months December 31,
 
Years Ended September 30,
 
2019
 
2018
 
2018
 
2017
Research and development
$
17,761

 
$
1,906

 
$
3,116

 
$
1,145

General and administrative
12,451

 
1,487

 
3,649

 
2,008

Capitalized to fixed assets
174

 
—

 
—

 
—

Total share-based compensation
$
30,386

 
$
3,393

 
$
6,765

 
$
3,153