Autolus Therapeutics plc Forest House 58 Wood Lane White City London W12 7RZ United Kingdom VIA EDGAR

April 8, 2019

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Ms. Mary Beth Breslin Ms. Christine Westbrook

Re:	Autolus Therapeutics plc
	Registration Statement on Form F-1 File No. 333-230767

        Acceleration Request

                Requested Date:   Wednesday, April 10, 2019

                Requested Time:  4:30 P.M. Eastern Time

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant (the “Registrant”) hereby requests that the U.S. Securities and Exchange Commission (the “Commission”) take appropriate action to cause the above-referenced Registration Statement on Form F-1 to become effective on April 10, 2019, at 4:30 p.m., Eastern Time, or as soon thereafter as is practicable, or at such later time as its counsel may orally request via telephone call to the staff. The Registrant hereby authorizes each of Darren DeStefano, Brian Leaf, Courtney Thorne and Katie Kazem of Cooley LLP, counsel to the Registrant, to make such request on its behalf.

Once the Registration Statement has been declared effective, please orally confirm that event with Darren DeStefano of Cooley LLP at + 1 703 456 8034, or in his absence, Courtney Thorne at + 1 617 937 2318. Thank you for your assistance with this matter.

[Signature Page Follows]

Sincerely,
AUTOLUS THERAPEUTICS PLC
By:	/s/ Christian Itin
	Christian Itin
	Chief Executive Officer
cc:	Matthias Alder, Autolus Therapeutics plc
	Darren DeStefano, Cooley LLP Christian Plaza, Cooley LLP Brian Leaf, Cooley LLP
	Courtney Thorne, Cooley LLP Katie Kazem, Cooley LLP