<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001730463</cik>
        <entityName>Autolus Therapeutics plc</entityName>
        <issuerAddress>
            <street1>c/o MediaWorks</street1>
            <street2>191 Wood Lane</street2>
            <city>London</city>
            <stateOrCountry>X0</stateOrCountry>
            <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
            <zipCode>W12 7FP</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(44) 20 3829 6230</issuerPhoneNumber>
        <jurisdictionOfInc>UNITED KINGDOM</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>Autolus Therapeutics Ltd</previousName>
        </edgarPreviousNameList>
        <entityType>Other</entityType>
        <entityTypeOtherDesc>Public Limited Company</entityTypeOtherDesc>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Christian</firstName>
                <lastName>Itin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Autolus Therapeutics plc</street1>
                <street2>c/o MediaWorks, 191 Wood Lane</street2>
                <city>London</city>
                <stateOrCountry>X0</stateOrCountry>
                <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
                <zipCode>W12 7FP</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Dolski</lastName>
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                <street2>c/o MediaWorks, 191 Wood Lane</street2>
                <city>London</city>
                <stateOrCountry>X0</stateOrCountry>
                <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
                <zipCode>W12 7FP</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Edgar</firstName>
                <lastName>Braendle</lastName>
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            <relatedPersonAddress>
                <street1>c/o Autolus Therapeutics plc</street1>
                <street2>c/o MediaWorks, 191 Wood Lane</street2>
                <city>London</city>
                <stateOrCountry>X0</stateOrCountry>
                <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
                <zipCode>W12 7FP</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Brochu</lastName>
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            <relatedPersonAddress>
                <street1>c/o Autolus Therapeutics plc</street1>
                <street2>c/o MediaWorks, 191 Wood Lane</street2>
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                <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
                <zipCode>W12 7FP</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Martin</firstName>
                <lastName>Pule</lastName>
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                <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
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            <relationshipClarification></relationshipClarification>
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            <relatedPersonName>
                <firstName>Christopher</firstName>
                <lastName>Vann</lastName>
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                <zipCode>W12 7FP</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
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                <lastName>Rice</lastName>
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            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName>H.</middleName>
                <lastName>Johnson</lastName>
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            <relatedPersonAddress>
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                <stateOrCountry>X0</stateOrCountry>
                <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
                <zipCode>W12 7FP</zipCode>
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            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Joseph</firstName>
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                <lastName>Azelby</lastName>
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                <zipCode>W12 7FP</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Linda</firstName>
                <lastName>Bain</lastName>
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            <relatedPersonAddress>
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                <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
                <zipCode>W12 7FP</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Berriman</lastName>
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            <relatedPersonAddress>
                <street1>c/o Autolus Therapeutics plc</street1>
                <street2>c/o MediaWorks, 191 Wood Lane</street2>
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                <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
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                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Cynthia</firstName>
                <lastName>Butitta</lastName>
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                <street2>c/o MediaWorks, 191 Wood Lane</street2>
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                <stateOrCountry>X0</stateOrCountry>
                <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
                <zipCode>W12 7FP</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Iannone</lastName>
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                <firstName>Elisabeth</firstName>
                <lastName>Leiderman</lastName>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Other</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2024-02-13</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>200000000</totalOfferingAmount>
            <totalAmountSold>200000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
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                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Autolus Therapeutics plc</issuerName>
                <signatureName>/s/ Christian Itin</signatureName>
                <nameOfSigner>Christian Itin</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2024-02-23</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
