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                 May 9, 2022

       Christian Itin, Ph.D.
       Chief Executive Officer and Director
       Autolus Therapeutics plc
       The MediaWorks
       191 Wood Lane
       White City
       London W12 7FP
       United Kingdom

                                                        Re: Autolus
Therapeutics plc
                                                            Registration
Statement on Form F-3
                                                            Filed May 4, 2022
                                                            File No. 333-264650

       Dear Christian Itin:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

              Please contact Michael Davis at 202-551-4385 or Celeste Murphy at
202-551-3257 with
       any questions.




                 Sincerely,


                 Division of Corporation Finance

                 Office of Life Sciences
       cc:                                              Courtney Thorne