CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenue:
Product revenue, net	$ 99,135	$ 12,095	$ 158,296	$ 19,799
Costs and operating expenses:
Research and development	16,485	19,236	51,100	71,864
Selling, general and administrative	24,677	20,759	70,736	63,207
Total operating expenses	52,722	42,762	154,570	140,304
Income (loss) from operations	46,413	(30,667)	3,726	(120,505)
Interest income	322	5	459	20
Income (loss) before income taxes	46,735	(30,662)	4,185	(120,485)
(Provision) benefit for income taxes	177,358	118	174,717	(1,106)
Net income (loss)	$ 224,093	$ (30,544)	$ 178,902	$ (121,591)
Net income (loss) per share attributable to common shareholders, basic	$ 3.23	$ (0.44)	$ 2.58	$ (1.78)
Net income (loss) per share attributable to common shareholders, diluted	$ 3.18	$ (0.44)	$ 2.55	$ (1.78)
Weighted average common shares outstanding, basic	69,445,071	68,662,673	69,305,755	68,444,061
Weighted average common shares outstanding, diluted	70,552,018	68,662,673	70,286,444	68,444,061
Comprehensive income (loss):
Net income (loss)	$ 224,093	$ (30,544)	$ 178,902	$ (121,591)
Other comprehensive income (loss):
Unrealized gain (loss) on short-term investments and currency translation adjustments, net of tax	20	(72)	(4)	(11)
Total other comprehensive income (loss)	20	(72)	(4)	(11)
Total comprehensive income (loss)	224,113	(30,616)	178,898	(121,602)
Product revenue, net
Revenue:
Product revenue, net	33,424	12,095	82,585	19,799
Costs and operating expenses:
Cost of goods sold	6,937	$ 2,767	16,185	$ 5,233
License and collaboration revenue
Revenue:
Product revenue, net	65,711		75,711
Costs and operating expenses:
Cost of goods sold	$ 4,623		$ 16,549