CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenue:
Product revenue, net	$ 26,972	$ 7,704	$ 59,161	$ 7,704
Costs and operating expenses:
Research and development	13,798	23,945	34,615	52,628
Selling, general and administrative	23,841	21,848	46,059	42,448
Total operating expenses	46,340	48,259	101,848	97,542
Loss from operations	(19,368)	(40,555)	(42,687)	(89,838)
Interest income	103	6	137	15
Loss before provision for income taxes	(19,265)	(40,549)	(42,550)	(89,823)
Provision for income taxes	(716)	(1,014)	(2,641)	(1,224)
Net loss	$ (19,981)	$ (41,563)	$ (45,191)	$ (91,047)
Net loss per share attributable to common shareholders-basic	$ (0.29)	$ (0.61)	$ (0.65)	$ (1.33)
Net loss per share attributable to common shareholders-diluted	$ (0.29)	$ (0.61)	$ (0.65)	$ (1.33)
Weighted average common shares outstanding-basic	69,289,972	68,395,703	69,213,860	68,332,943
Weighted average common shares outstanding-diluted	69,289,972	68,395,703	69,213,860	68,332,943
Comprehensive loss:
Net loss	$ (19,981)	$ (41,563)	$ (45,191)	$ (91,047)
Other comprehensive loss:
Unrealized gain (loss) on short-term investments and currency translation adjustments, net of tax	13	48	(24)	61
Total other comprehensive gain (loss)	13	48	(24)	61
Total comprehensive loss	(19,968)	(41,515)	(45,215)	(90,986)
Product revenue, net
Revenue:
Product revenue, net	26,972	7,704	49,161	7,704
Costs and operating expenses:
Cost of goods sold	5,029	$ 2,466	9,248	$ 2,466
Collaboration revenue
Revenue:
Product revenue, net			10,000
Costs and operating expenses:
Cost of goods sold	$ 3,672		$ 11,926