Nature of the Business and Basis of Presentation (Details) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Liquidity
Accumulated deficit	$ 720,588				$ 720,588		$ 675,397
Net losses	19,981	$ 25,210	$ 41,563	$ 49,484	45,191	$ 91,047
Cash used in operations					44,670	$ 78,905
Cash, cash equivalents and short-term investments	$ 138,208				$ 138,208