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License and Acquisition Agreements - Primatope Stock Purchase Option Agreement (Details)
$ in Thousands
1 Months Ended 12 Months Ended
Mar. 31, 2019
USD ($)
Sep. 30, 2017
USD ($)
item
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Jun. 30, 2019
USD ($)
License and Acquisition Agreements            
Research and development     $ 112,042 $ 135,001 $ 86,597  
Primatope | Stock Option Purchase Agreement            
License and Acquisition Agreements            
Upfront payment for initial option period   $ 500        
Payment for extension of option period         800  
Primatope Acquisition            
License and Acquisition Agreements            
Purchase price $ 15,000          
Upfront consideration payable on exercise of call option to acquire all outstanding equity 10,000          
Milestone payment payable after achievement of specified milestones $ 5,000         $ 3,000
Research and development       $ 18,000 $ 800  
Maximum | Primatope | Stock Option Purchase Agreement            
License and Acquisition Agreements            
Number of extensions allowed for initial option period | item   3        
Total aggregate extension payments   $ 800