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License and Acquisition Agreements - Novo Nordisk License Agreement (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Aug. 31, 2017
Dec. 31, 2019
Dec. 31, 2018
License and Acquisition Agreements      
Milestone payments due   $ 0 $ 0
Research and development expense   135,001 86,597
License Agreement | Novo Nordisk      
License and Acquisition Agreements      
Upfront payment for exchange of rights $ 1,500    
Consideration payable upon completion of technology transfer 150    
Milestone payment payable after achievement of specified milestones $ 1,000    
Research and development expense   $ 0 $ 154