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License and Acquisition Agreements - Novo Nordisk License Agreement (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Aug. 31, 2017
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
License and Acquisition Agreements          
Research and development   $ 20,644 $ 14,008 $ 50,475 $ 26,426
Novo Nordisk Agreement          
License and Acquisition Agreements          
Upfront payment for exchange of rights $ 1,500        
Consideration payable upon completion of the technology transfer 150        
Milestone payment payable after achievement of specified milestones $ 1,000        
Milestone payments due       0 0
Research and development expense, Milestone   $ 4   $ 154  
Research and development     $ 1,500   $ 1,500