X0508 4 2025-11-17 0 0001729427 CNS Pharmaceuticals, Inc. CNSP 0001546797 Climaco John M C/O CNS PHARMACEUTICALS, INC. 100 WEST LOOP SOUTH, SUITE 900 HOUSTON TX 77027 1 1 0 0 Chief Executive Officer 0 Option to purchase common stock 30 2025-11-17 4 A 0 9761 0 A 2035-11-17 Common Stock 9761 9761 D The option grant was approved by the compensation committee of CNS Pharmaceutical, Inc.'s board of directors on March 11, 2025 (the "Grant Date"), subject to shareholder approval of the stock option plan under which the option was granted. CNS Pharmaceutical, Inc.'s shareholders approved the plan at the company's annual meeting on November 17, 2025. The options set forth in the table vest as follows: 50% on the six-month anniversary of the Grant Date, 25% on the 12-month anniversary of the Grant Date, and 25% on the 18-month anniversary of the Grant Date, subject to the reporting person's continued employment on each vesting date. Issued in connection with the reporting person's employment with the Company. /s/ Christopher Downs, Attorney-in-Fact 2025-11-19