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        <filerCredentials>
          <filerCik>0001729427</filerCik>
          <filerCcc>XXXXXXXX</filerCcc>
        </filerCredentials>
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      <period>12-31-2018</period>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>false</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
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      <issuerInfo>
        <nameOfIssuer>CNS Pharmaceuticals, Inc.</nameOfIssuer>
        <legalStatus>
          <legalStatusForm>Corporation</legalStatusForm>
          <jurisdictionOrganization>NV</jurisdictionOrganization>
          <dateIncorporation>07-27-2017</dateIncorporation>
        </legalStatus>
        <issuerAddress>
          <com:street1>2100 WEST LOOP SOUTH</com:street1>
          <com:street2>SUITE 900</com:street2>
          <com:city>HOUSTON</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77027</com:zipCode>
        </issuerAddress>
        <issuerWebsite>www.cnspharma.com</issuerWebsite>
      </issuerInfo>
    </issuerInformation>
    <offeringInformation></offeringInformation>
    <annualReportDisclosureRequirements>
      <currentEmployees>4.00</currentEmployees>
      <totalAssetMostRecentFiscalYear>683333.00</totalAssetMostRecentFiscalYear>
      <totalAssetPriorFiscalYear>162194.00</totalAssetPriorFiscalYear>
      <cashEquiMostRecentFiscalYear>282736.00</cashEquiMostRecentFiscalYear>
      <cashEquiPriorFiscalYear>110543.00</cashEquiPriorFiscalYear>
      <actReceivedMostRecentFiscalYear>0.00</actReceivedMostRecentFiscalYear>
      <actReceivedPriorFiscalYear>0.00</actReceivedPriorFiscalYear>
      <shortTermDebtMostRecentFiscalYear>1232631.00</shortTermDebtMostRecentFiscalYear>
      <shortTermDebtPriorFiscalYear>220726.00</shortTermDebtPriorFiscalYear>
      <longTermDebtMostRecentFiscalYear>0.00</longTermDebtMostRecentFiscalYear>
      <longTermDebtPriorFiscalYear>0.00</longTermDebtPriorFiscalYear>
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    </annualReportDisclosureRequirements>
    <signatureInfo>
      <issuerSignature>
        <issuer>/s/ John Climaco</issuer>
        <issuerSignature>John Climaco</issuerSignature>
        <issuerTitle>Chief Executive Officer</issuerTitle>
      </issuerSignature>
      <signaturePersons>
        <signaturePerson>
          <personSignature>/s/ John Climaco</personSignature>
          <personTitle>President, Chief Executive Officer and Director</personTitle>
          <signatureDate>04-29-2019</signatureDate>
        </signaturePerson>
        <signaturePerson>
          <personSignature>/s/ Matthew Lourie</personSignature>
          <personTitle>Chief Financial Officer</personTitle>
          <signatureDate>04-29-2019</signatureDate>
        </signaturePerson>
        <signaturePerson>
          <personSignature>/s/ Jerzy (George) Gumulka</personSignature>
          <personTitle>Director</personTitle>
          <signatureDate>04-29-2019</signatureDate>
        </signaturePerson>
        <signaturePerson>
          <personSignature>/s/ Carl Evans</personSignature>
          <personTitle>Director</personTitle>
          <signatureDate>04-29-2019</signatureDate>
        </signaturePerson>
        <signaturePerson>
          <personSignature>/s/ Jeffry Keyes</personSignature>
          <personTitle>Director</personTitle>
          <signatureDate>04-29-2019</signatureDate>
        </signaturePerson>
        <signaturePerson>
          <personSignature>/s/ Andrzej Andraczke</personSignature>
          <personTitle>Directror</personTitle>
          <signatureDate>04-29-2019</signatureDate>
        </signaturePerson>
      </signaturePersons>
    </signatureInfo>
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