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    <periodOfReport>2022-11-10</periodOfReport>

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    <issuer>
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        <issuerName>Skye Bioscience, Inc.</issuerName>
        <issuerTradingSymbol>SKYE</issuerTradingSymbol>
    </issuer>

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            <rptOwnerName>Emerald Health Sciences Inc.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>OFFICE 8262</rptOwnerStreet1>
            <rptOwnerStreet2>THE LANDING, 200-375 WATER ST.</rptOwnerStreet2>
            <rptOwnerCity>VANCOUVER</rptOwnerCity>
            <rptOwnerState>A1</rptOwnerState>
            <rptOwnerZipCode>V6B 0M9</rptOwnerZipCode>
            <rptOwnerStateDescription>BRITISH COLUMBIA, CANADA</rptOwnerStateDescription>
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            <isOfficer>0</isOfficer>
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            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
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    <footnotes>
        <footnote id="F1">Warrants were acquired pursuant to a merger between Issuer and Emerald Health Therapeutics, Inc. (&quot;Emerald&quot;), whereby Reporting Person's outstanding warrants to purchase Emerald common stock were exchanged for warrants to purchase Issuer common stock.</footnote>
        <footnote id="F2">Aggregate exercise price for the warrants was paid through a reduction in the debt Issuer owed to Reporting Person under the Multi Draw Credit Facility.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Stephen Hall, CFO of Emerald Health Sciences Inc.</signatureName>
        <signatureDate>2023-03-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
