X0306 4 2021-02-12 0 0001707502 Solid Biosciences Inc. SLDB 0001727460 Ganot Ilan C/O SOLID BIOSCIENCES INC. 141 PORTLAND STREET, 5TH FLOOR CAMBRIDGE MA 02139 1 1 0 0 CEO & President Common Stock 2021-02-12 4 S 0 457 7.6611 D 3026 I Wife Common Stock 290914 I See footnote Common Stock 1199821 D This sale was made to cover withholding taxes following the vesting of the previously granted restricted stock units. Represents 290,914 shares held by Adam Ganot and Annie Ganot, and their successors, as the trustees for the Ilan Ganot 2017 Irrevocable Trust dated March 3, 2017. Represents 1,139,190 shares held by Mr. Ganot as an individual, and 60,631 shares held by Mr. Ganot and Annie Ganot as joint tenants with right of survivorship. /s/ Ilan Ganot 2021-02-16