X0306 4 2022-12-02 0 0001707502 Solid Biosciences Inc. SLDB 0001727460 Ganot Ilan C/O SOLID BIOSCIENCES INC. 500 RUTHERFORD AVENUE, THIRD FLOOR CHARLESTOWN MA 02129 1 0 0 0 Stock Option (Right to Buy) 6.77 2022-12-02 4 A 0 13333 0.00 A 2032-12-02 Common Stock 13333 13333 D Restricted Stock Units 2022-12-02 4 A 0 6333 0.00 A Common Stock 6333 6333 D This option (the "Ganot Option") was granted on December 2, 2022 (the "Grant Date") and vests in equal quarterly installments with the first installment vesting three months from the Grant Date and the final installment vesting date being the date that is 12 months from the Separation Date (as defined in that certain Executive Transition and Separation Agreement between the issuer and Mr. Ganot, the "Ganot Agreement"); provided that in the event of a Change in Control (as defined in the Ganot Agreement) the Ganot Option shall accelerate in full. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock (the "Ganot RSUs"). The Ganot RSUs were granted on the Grant Date and vest in equal quarterly installments with the first installment vesting three months from the Grant Date and the final installment vesting date being the date that is 12 months from the Separation Date (as defined in the Ganot Agreement); provided that in the event of a Change in Control (as defined in the Ganot Agreement) the Ganot RSUs shall accelerate in full. Exhibit Index: 24.1 Power of Attorney /s/ David Tyronne Howton as attorney-in-fact for Ilan Ganot 2022-12-05