X0508 4 2024-05-28 0001645469 Monopar Therapeutics MNPR 0001727334 Robinson Chandler 1000 SKOKIE BLVD SUITE 350 WILMETTE IL 60091 1 1 Chief Executive Officer 0 Common Stock 2024-05-28 4 X 0 84000 0.001 A 250130.80 D Common Stock 4111272.88 I See Footnote Common Stock 166667 I See Footnote Stock Options 0.001 2024-05-28 4 X 0 84000 0 D 2026-04-03 Common Stock 84000 0 D This transaction involved a cash exercise of a stock option without a subsequent sale of the underlying shares of common stock. This is based upon the 4,111,272.88 shares of Monopar Common Stock that Tactic Pharma LLC indirectly controls through TacticGem LLC. As a manager of Tactic Pharma LLC, Dr. Robinson may be deemed to share voting and dispositive power over these 4,111,272.88 shares. Dr. Robinson disclaims beneficial ownership of the 4,111,272.88 shares held by Tactic Pharma LLC, except to the extent of his pecuniary interest therein. This is based upon the 166,667 shares of Monopar Common Stock that Tactic Pharma LLC directly owns. As a manager of Tactic Pharma LLC, Dr. Robinson may be deemed to share voting and dispositive power over these 166,667 shares. Dr. Robinson disclaims beneficial ownership of the 166,667 shares held by Tactic Pharma LLC, except to the extent of his pecuniary interest therein Reflects options to purchase up to 84,000 shares of common stock granted to Dr. Robinson on April 4, 2016 for his services as a director and officer of Monopar Therapeutics. The options vested 50% upon grant date, 25% upon the 6-month anniversary of grant date, and 25% upon the 1-year anniversary of grant date. /s/ Kim R Tsuchimoto, Attorney-in-fact 2024-05-30