144 0001358219 XXXXXXXX LIVE 0001727196 Scholar Rock Holding Corp. 001-38501 301 Binney Street, 3rd Floor Cambridge MA 02142 857-259-3860 Edward Myles Former Officer Common J.P. Morgan Securities LLC

390 Madison Avenue 6th Floor New York NY 10017

19599 636967 94676763 06/05/2025 Nasdaq Common 06/05/2025 Stock Option Exercise Issuer N 19599 06/05/2025 Cash N Edward H. Myles

C/o Issuer 301 Binney Street, 3rd Floor Cambridge MA 02142

Common 03/10/2025 142292 5005107 06/05/2025 /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Edward Myles