CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss	$ (51,950)	$ (58,378)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,493	1,227
Amortization of debt discount and debt issuance costs	389	167
Loss on disposal of property and equipment	32	24
Equity-based compensation	13,619	10,899
Amortization/accretion of investment securities	291	517
Non-cash operating lease expense	3,382	3,107
Change in operating assets and liabilities:
Prepaid expenses and other current assets	(6,126)	(4,355)
Other assets	(62)
Accounts payable	(1,394)	(1,779)
Accrued expenses	17	1,227
Operating lease liabilities	(3,571)	(1,937)
Deferred revenue	(33,193)	(9,303)
Other liabilities	(231)	227
Net cash used in operating activities	(77,304)	(58,357)
Cash flows from investing activities:
Purchases of property and equipment	(920)	(3,295)
Purchases of marketable securities	(80,134)	(30,131)
Maturities of marketable securities	55,000	135,000
Net cash (used in) provided by investing activities	(26,054)	101,574
Cash flows from financing activities:
Proceeds from sale of common shares, pre-funded warrants and warrants to purchase common shares, net of issuance costs	195,770
Proceeds from stock option exercises	483	3,354
Other		(10)
Net cash provided by financing activities	196,253	3,344
Net increase in cash, cash equivalents and restricted cash	92,895	46,561
Cash, cash equivalents and restricted cash, beginning of period	215,333	162,856
Cash, cash equivalents and restricted cash, end of period	308,228	209,417
Supplemental disclosure of non-cash items:
Property and equipment purchases in accounts payable and accrued expenses		635
Offering costs in accrued expenses	445
Supplemental cash flow information:
Cash paid for interest	$ 1,836	$ 992