X0202 SCHEDULE 13G/A 0001425738 XXXXXXXX LIVE 11 Common Stock, par value $0.001 per share 06/30/2026 0001727196 Scholar Rock Holding Corporation 80706P103 301 Binney Street, 3rd Floor Cambridge MA 02142 Rule 13d-1(c) Redmile Group, LLC DE 0.00 4311092.00 0.00 4311092.00 4311092.00 N 3.6 IA OO The information in Item 4 relating to the shares of the Issuer's common stock, par value $0.001 per share ("Common Stock"), that are or may be deemed beneficially owned by Redmile Group, LLC and the calculation of the percent of such class of securities is incorporated herein by reference. Jeremy C. Green X0 0.00 4311092.00 0.00 4311092.00 4311092.00 N 3.6 HC IN The information in Item 4 relating to the shares of Common Stock that are or may be deemed beneficially owned by Jeremy C. Green and the calculation of the percent of such class of securities is incorporated herein by reference. RedCo II Master Fund, L.P. E9 0.00 0.00 0.00 0.00 0.00 N 0.0 PN FI Scholar Rock Holding Corporation 301 Binney Street, 3rd Floor, Cambridge, MA 02142 Redmile Group, LLC Jeremy C. Green RedCo II Master Fund, L.P. Redmile Group, LLC 900 Larkspur Landing Circle, Suite 270 Larkspur, California 94939 Jeremy C. Green c/o Redmile Group, LLC (NY Office) 45 W. 27th Street, Floor 11 New York, NY 10001 RedCo II Master Fund, L.P. c/o Redmile Group, LLC 900 Larkspur Landing Circle, Suite 270 Larkspur, California 94939 Redmile Group, LLC: Delaware Jeremy C. Green: United Kingdom RedCo II Master Fund, L.P.: Cayman Islands Y Redmile Group, LLC - 4,311,092 (1) Jeremy C. Green - 4,311,092 (1) RedCo II Master Fund, L.P. - 0 Redmile Group, LLC - 3.6% (2) Jeremy C. Green - 3.6% (2) RedCo II Master Fund, L.P. - 0.0% Redmile Group, LLC - 0 Jeremy C. Green - 0 RedCo II Master Fund, L.P. - 0 Redmile Group, LLC - 4,311,092 (1) Jeremy C. Green - 4,311,092 (1) RedCo II Master Fund, L.P. - 0 Redmile Group, LLC - 0 Jeremy C. Green - 0 RedCo II Master Fund, L.P. - 0 Redmile Group, LLC - 4,311,092 (1) Jeremy C. Green - 4,311,092 (1) RedCo II Master Fund, L.P. - 0 (1) Redmile Group, LLC's ("Redmile") and Jeremy C. Green's beneficial ownership of the Issuer's Common Stock is comprised of 4,311,092 shares of Common Stock. All of such shares of Common Stock are directly owned by certain investment vehicles for which Redmile is the investment manager (the "Redmile Funds"). Redmile may be deemed to beneficially own these securities in its capacity as their investment manager with discretion to vote and dispose of all shares of Common Stock held by the Redmile Funds. Mr. Green also may be deemed to beneficially own these securities as the principal of Redmile. Redmile and Mr. Green each disclaim beneficial ownership of these securities, except to the extent of its or his pecuniary interest in such securities, if any. (2) Percentage for Redmile and Jeremy Green based on 119,828,338 shares of Common Stock outstanding as of May 4, 2026, as reported by the Issuer in its Form 10-Q for the quarterly period ended March 31, 2026 filed with the SEC on May 7, 2026. N Y Y N See the response to Item 4. Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Redmile Group, LLC /s/ Jeremy C. Green 08/14/2026 Jeremy C. Green /s/ Jeremy C. Green 08/14/2026 RedCo II Master Fund, L.P. /s/ Jeremy C. Green 08/14/2026