X0202 SCHEDULE 13G/A 0001425738 XXXXXXXX LIVE 10 Common Stock, par value $0.001 per share 03/31/2026 0001727196 Scholar Rock Holding Corporation 80706P103 301 Binney Street, 3rd Floor Cambridge MA 02142 Rule 13d-1(c) Redmile Group, LLC DE 0.00 9066621.00 0.00 9066621.00 9066621.00 N 7.6 IA OO The information in Item 4 relating to the shares of the Issuer's common stock ("Common Stock") that are or may be deemed beneficially owned by Redmile Group, LLC ("Redmile") is incorporated herein by reference. Percentage based on 119,103,774 shares of Common Stock outstanding as of March 31, 2026, as reported by the Issuer in its Definitive Proxy Statement on Schedule 14A filed with the SEC on April 22, 2026 (the "Schedule 14A"). Jeremy C. Green X0 0.00 9066621.00 0.00 9066621.00 9066621.00 N 7.6 HC IN The information in Item 4 relating to the shares of Common Stock that are or may be deemed beneficially owned by Jeremy C. Green is incorporated herein by reference. Percentage based on 119,103,774 shares of Common Stock outstanding as of March 31, 2026, as reported by the Issuer in the Schedule 14A. RedCo II Master Fund, L.P. E9 0.00 6907180.00 0.00 6907180.00 6907180.00 N 5.8 PN FI Percentage based on 119,103,774 shares of Common Stock outstanding as of March 31, 2026, as reported by the Issuer in the Schedule 14A. Scholar Rock Holding Corporation 301 Binney Street, 3rd Floor, Cambridge, MA 02142 Redmile Group, LLC Jeremy C. Green RedCo II Master Fund, L.P. Redmile Group, LLC 900 Larkspur Landing Circle, Suite 270 Larkspur, California 94939 Jeremy C. Green c/o Redmile Group, LLC (NY Office) 45 W. 27th Street, Floor 11 New York, NY 10001 RedCo II Master Fund, L.P. c/o Redmile Group, LLC 900 Larkspur Landing Circle, Suite 270 Larkspur, California 94939 Redmile Group, LLC: Delaware Jeremy C. Green: United Kingdom RedCo II Master Fund, L.P.: Cayman Islands Y Redmile Group, LLC - 9,066,621 (1) Jeremy C. Green - 9,066,621 (1) RedCo II Master Fund, L.P. - 6,907,180 Redmile Group, LLC - 7.6% (2) Jeremy C. Green - 7.6% (2) RedCo II Master Fund, L.P. - 5.8% (2) Redmile Group, LLC - 0 Jeremy C. Green - 0 RedCo II Master Fund, L.P. - 0 Redmile Group, LLC - 9,066,621 (1) Jeremy C. Green - 9,066,621 (1) RedCo II Master Fund, L.P. - 6,907,180 Redmile Group, LLC - 0 Jeremy C. Green - 0 RedCo II Master Fund, L.P. - 0 Redmile Group, LLC - 9,066,621 (1) Jeremy C. Green - 9,066,621 (1) RedCo II Master Fund, L.P. - 6,907,180 (1) As of March 31, 2026, Redmile's and Jeremy C. Green's beneficial ownership of Common Stock is comprised of 9,066,621 shares of Common Stock. All of such shares of Common Stock are directly owned by certain investment vehicles, including RedCo II Master Fund, L.P., for which Redmile is the investment manager (the "Redmile Funds"). Redmile may be deemed to beneficially own these securities in its capacity as the investment manager with discretion to vote and dispose of all shares of Common Stock held by the Redmile Funds. Mr. Green also may be deemed to beneficially own these securities as the principal of Redmile. Redmile and Mr. Green each disclaim beneficial ownership of these securities, except to the extent of its or his pecuniary interest in such securities, if any. (2) Percentage based on 119,103,774 shares of Common Stock outstanding as of March 31, 2026, as reported by the Issuer in the Schedule 14A. Y Y N See the response to Item 4. Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Redmile Group, LLC /s/ Jeremy C. Green 05/15/2026 Jeremy C. Green /s/ Jeremy C. Green 05/15/2026 RedCo II Master Fund, L.P. /s/ Jeremy C. Green 05/15/2026