X0508 4 2025-05-21 0000927653 MCKESSON CORP MCK 0001727010 Vitalone Britt J. 6555 STATE HWY 161 IRVING TX 75039 0 1 0 0 EVP & CFO 1 Common Stock 2025-05-21 4 M 0 1207 0 A 21571.377 D Common Stock 2025-05-21 4 F 0 475 718.73 D 21096.377 D Common Stock 2025-05-22 4 S 0 6336 717.3 D 14760.377 D Common Stock 550.1311 I By the McKesson Corporation 401(k) Retirement Savings Plan Restricted Stock Units (RSUs) 0 2025-05-21 4 M 0 1207 0 D Common Stock 1207 2414 D This transaction represents a withholding of shares to cover taxes applicable to a vesting of RSUs also reported on this Form 4. Sale pursuant to a previously adopted plan dated November 9, 2024, in compliance with Rule 10b5-1(c). These RSUs vested as to 1/3 on 5/21/2025, and will vest 1/3 on 5/21/2026 and 1/3 on 5/21/2027. /s/ Sarah Ahmad Ali, Attorney-in-fact 2025-05-23