X0306 4 2019-03-20 0 0001103021 BIODELIVERY SCIENCES INTERNATIONAL INC BDSI 0001726687 Plesha Scott M. C/O BIODELIVERY SCIENCES INTL, INC., 4131 PARKLAKE AVE. SUITE 225 RALEIGH NC 27612 0 1 0 0 See Remarks Common Stock 2019-03-20 4 M 0 8333 0.00 A 232337 D Common Stock 2019-03-20 4 A 0 8333 0.00 A 240670 D Common Stock 2019-03-20 4 M 0 20833 0.00 A 261503 D Common Stock 2019-03-20 4 A 0 20833 0.00 A 282833 D Restricted Stock Units 0.00 2019-03-20 4 M 0 8333 0.00 D 2020-03-19 Common Stock 8333 8334 D Restricted Stock Units 0.00 2019-03-20 4 A 0 8333 0.00 D 2020-03-19 Common Stock 8333 8334 D Restricted Stock Units 0.00 2019-03-20 4 M 0 20833 0.00 D 2021-03-19 Common Stock 20833 41667 D Restricted Stock Units 0.00 2019-03-20 4 A 0 20833 0.00 D 2021-03-19 Common Stock 20833 41667 D The shares of common stock were acquired by the Reporting Person as a result of the vesting of 8,333 of Restricted Stock Units (RSUs) granted to the Reporting Person on February 6, 2017 under the Issuer's 2011 Equity Incentive Plan, as amended (the EIP). The remainder of the RSUs under this grant will vest in the first open window upon the filing of the Company's Annual Report in March 2020. The shares of common stock were acquired by the Reporting Person as a result of the vesting of 8,333 Performance RSUs granted to the Reporting Person on February 6, 2017 under the EIP, subject to certain performance measures. The remainder of the PRSUs under this grant will vest after the first open window upon the filing of the Company's Annual Report in March 2020 subject to certain performance measures. The shares of common stock were acquired by the Reporting Person as a result of the vesting of 20,833 of RSUs granted to the Reporting Person on February 18, 2018 under the EIP. The remainder of the RSUs under this grant will vest in the first open window upon the filing of the Company's Annual Report in March 2020 and March 2021. The shares of common stock were acquired by the Reporting Person as a result of the vesting of 20,833 Performance RSUs granted to the Reporting Person on February 18, 2018 under the EIP, subject to certain performance measures. The remainder of the PRSUs under this grant will vest after the first open window upon the filing of the Company's Annual Report in March 2020 subject to certain performance measures. President and Chief Commercial Officer /s/ Scott Plesha 2019-03-22