X0202 SCHEDULE 13G/A 0002005369 XXXXXXXX LIVE 4 Class A Common Stock, par value $0.00001 per share 03/31/2026 0001726445 Seer, Inc. 81578P106 3800 Bridge Parkway Suite 102 Redwood City CA 94065 Rule 13d-1(c) Invus Public Equities, L.P. D0 2458673.00 0.00 2458673.00 0.00 2458673.00 N 4.4 PN Invus Public Equities Advisors, LLC DE 2458673.00 0.00 2458673.00 0.00 2458673.00 N 4.4 OO Invus Global Management, LLC DE 2458673.00 0.00 2458673.00 0.00 2458673.00 N 4.4 OO Siren, L.L.C. DE 2458673.00 0.00 2458673.00 0.00 2458673.00 N 4.4 OO Raymond Debbane R1 2458673.00 0.00 2458673.00 0.00 2458673.00 N 4.4 IN Seer, Inc. 3800 Bridge Parkway, Suite 102, Redwood City, CA, 94065 See Item 2(c) below. See Item 2(c) below. (i) Invus Public Equities, L.P. ("Invus Public Equities") 750 Lexington Avenue, 30th Floor, New York, NY 10022 Citizenship: Bermuda limited partnership (ii) Invus Public Equities Advisors, LLC ("Invus PE Advisors") 750 Lexington Avenue, 30th Floor, New York, NY 10022 Citizenship: Delaware limited liability company (iii) Invus Global Management, LLC ("Global Management") 750 Lexington Avenue, 30th Floor, New York, NY 10022 Citizenship: Delaware limited liability company (iv) Siren, L.L.C. ("Siren") c/o The Invus Group, LLC, 750 Lexington Avenue, 30th Floor, New York, NY 10022 Citizenship: Delaware limited liability company (v) Raymond Debbane 750 Lexington Avenue, 30th Floor, New York, NY 10022 Citizenship: Panama Y As of March 31, 2026, Invus Public Equities directly held 2,458,673 shares of Class A common stock, par value $0.00001 per share (the "Shares") of Seer, Inc. (the "Issuer"). Invus PE Advisors, as the general partner of Invus Public Equities, controls Invus Public Equities and, accordingly, may be deemed to beneficially own the Shares directly held by Invus Public Equities. Global Management, as the managing member of Invus PE Advisors, controls Invus PE Advisors and, accordingly, may be deemed to beneficially own the Shares that Invus PE Advisors may be deemed to beneficially own. Siren, as the managing member of Global Management, controls Global Management and, accordingly, may be deemed to beneficially own the Shares that Global Management may be deemed to beneficially own. Mr. Raymond Debbane, as the managing member of Siren, controls Siren and, accordingly, may be deemed to beneficially own the Shares that Siren may be deemed to beneficially own. As of March 31, 2026, each of the Reporting Persons may be deemed to be the beneficial owner of the percentage of Shares listed on such Reporting Person's cover page. Calculations of the percentage of Shares beneficially owned are based on 56,420,772 Shares outstanding as of February 23, 2026, as reported by the Issuer its annual report on Form 10-K as filed with the Securities and Exchange Commission on March 2, 2026. See each cover page hereof. See each cover page hereof. See each cover page hereof. See each cover page hereof. N Y Y Y Y Y N Each of the Reporting Persons hereby makes the following certification: By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Invus Public Equities, L.P. /s/ Raymond Debbane 05/04/2026 Invus Public Equities Advisors, LLC /s/ Raymond Debbane 05/04/2026 Invus Global Management, LLC /s/ Raymond Debbane 05/04/2026 Siren, L.L.C. /s/ Raymond Debbane 05/04/2026 Raymond Debbane /s/ Raymond Debbane 05/04/2026