X0306 4 2020-06-19 0 0001598646 Minerva Neurosciences, Inc. NERV 0001724897 Russell Richard E. C/O MINERVA NEUROSCIENCES, INC. 1601 TRAPELO ROAD, SUITE 284 WALTHAM MA 02451 0 1 0 0 President Employee Stock Option (right to buy) 7.11 2020-06-19 4 A 0 185025 0.00 A 2029-12-31 Common Stock 185025 185025 D This option was granted by Issuer's Board of Directors on December 31, 2019 contingent upon stockholder approval of an amendment and restatement of Issuer's equity incentive plan to increase the number of shares available for issuance under such plan, which was received on June 19, 2020. This option vests 25% on December 31, 2020 and then in quarterly installments over 3 years thereafter. /s/ Ryan Sansom, Attorney-in-Fact 2020-08-17