X0306 4/A 2020-08-05 2020-08-07 0 0001645460 Cue Biopharma, Inc. CUE 0001724870 Sandercock Colin 21 ERIE STREET CAMBRIDGE MA 02139 0 1 0 0 SVP, General Counsel and Sec Common Stock 2020-08-05 4 M 0 13374 7.50 A 30499 D Common Stock 2020-08-05 4 S 0 13374 20.00 D 17125 D Stock Option (right to buy) 7.50 2020-08-05 4 M 0 13374 0.00 D 2024-12-27 Common Stock 13374 130000 D This Form 4 amends and restates the original Form 4 filed on August 7, 2020 (the "Original Form 4") to include 100 Stock Options and shares of Common Stock that were omitted from the Original Form 4 due to clerical error. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 24, 2020. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $20.00 to $20.01, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote. These Stock Options become exercisable in eight equal semi-annual installments beginning June 5, 2018. /s/ Colin Sandercock by Mark Busch, as attorney-in-fact 2020-08-10