0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Statements of Operations (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952157 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952158 - Statement - Consolidated Statements of Cash Flows (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Organization, Liquidity and Capital Resources link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Related Party - Gilead Sciences, Inc. link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - License and Collaborations link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Revenues link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Defined Contribution Plan link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Cash, Cash Equivalents and Marketable Securities link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Consolidated Balance Sheet Components link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Long-Term Debt link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952174 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952175 - Disclosure - Commitments link:presentationLink link:calculationLink link:definitionLink 9952176 - Disclosure - Business segment link:presentationLink link:calculationLink link:definitionLink 9952177 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Revenues (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Cash, Cash Equivalents and Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Property and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Consolidated Balance Sheet Components (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Long-Term Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Business segment (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Organization, Liquidity and Capital Resources - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Related Party - Gilead Sciences, Inc. - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - License and Collaborations - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Revenues - Summary of Revenues by Collaboration, Category of Revenue and Method of Recognition (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Revenues - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Revenues - Summary of Revenue Recognized as a Result of Changes in Deferred Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Revenues - Summary of Transaction Price and Allocation of Transaction Price to the Performance Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Income Taxes - Schedule of Loss Before Provision for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Income Taxes - Schedule of Components of Provision for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Income Taxes - Schedule of Income Tax Paid (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Income Taxes - Schedule of Effective Tax Rate of Provision for Income Taxes Differs from Federal Statutory Rate (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Income Taxes - Schedule of Significant Components of Deferred Tax Assets for Federal and State Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Income Taxes - Summary of Activity Related to Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Net Loss Per Share - Computation of Basic and Diluted Net Income (Loss) Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Net Loss Per Share - Summary of Outstanding Potentially Dilutive Securities Excluded from Computation of Diluted Net Income (Loss) per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Stock-Based Compensation - Summary of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Stock-Based Compensation - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Units Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Stock-Based Compensation - Summary of Information Regarding Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Stock-Based Compensation - Schedule of Assumptions Used to Calculate Fair Value and the Weighted-Average Grant Date Fair Value of Stock Options Granted (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Defined Contribution Plan - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Cash, Cash Equivalents and Marketable Securities - Schedule of Amortized Cost, Gross Unrealized Gains and Losses and Fair Value of Our Cash, Cash Equivalents and Marketable Securities Considered as Available for Sale by Type of Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Cash, Cash Equivalents and Marketable Securities - Schedule of Fair Values of Our Cash, Cash Equivalents and Marketable Securities by Location in Consolidated Balance Sheets and Contractual Maturity (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Cash, Cash Equivalents and Marketable Securities - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Cash, Cash Equivalents and Marketable Securities - Reconciliation of Cash, Cash Equivalents and Restricted Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Property and Equipment - Summary of Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Consolidated Balance Sheet Components - Summary of Prepaid and Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Consolidated Balance Sheet Components - Summary of Other Current Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Long-Term Debt - Schedule of Long-Term Debt Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Long-Term Debt - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Long-Term Debt - Schedule of Maturities of Long-Term Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Leases - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Leases - Summary of Information Related to Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Leases - Summary of Cash and Non-cash Information Related to Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Leases - Summary of Future Minimum Lease Payments (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Leases - Summary of Future Minimum Lease Payments (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Stockholders' Equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Fair Value Measurements - Schedule of Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Fair Value Measurements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Fair Value Measurements - Summary of Changes of Liabilities for Sale of Future Royalties (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Commitments - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Business segment - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Business segment - Schedule of Segment Reporting Information, by Segment (Details) link:presentationLink link:calculationLink link:definitionLink