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Stock-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2025
Share-Based Payment Arrangement [Abstract]  
Summary of Stock-Based Compensation Expense
The following table reflects the components of stock-based compensation expense recognized in our Consolidated Statements of Operations (in millions):
Year Ended December 31,
202520242023
Research and development$31 $38 $35 
General and administrative29 38 38 
Total stock-based compensation$60 $76 $73 
Summary of Restricted Stock Units Activity The following table summarizes information regarding our RSUs for the year ended December 31, 2025:
Total RSUs
(in millions) 		Weighted
Average
Grant Date Fair Value Per Share
Nonvested at December 31, 20242.2$18.07 
RSUs granted2.5$13.00 
RSUs vested(1.3)$17.11 
RSUs forfeited or canceled(0.5)$15.94 
Nonvested at December 31, 20252.9$14.58 
Summary of Information Regarding Stock Options The following table summarizes information regarding our stock options for the year ended December 31, 2025:
Shares
Subject to
Outstanding
Options
(in millions) 		Weighted
Average
Exercise
Price Per
Share		Weighted
Average
Remaining
Contractual
Term (in years)		Aggregate
Intrinsic
Value
(in millions)
Outstanding at December 31, 202415.5$20.31 
Options granted3.4$12.75 
Options exercised(0.4)$11.60 
Options forfeited or canceled(1.6)$22.27 
Outstanding at December 31, 202516.9$18.79 6.27$118 
Options vested and expected to vest as of December 31, 202516.9$18.79 6.27$118 
Options exercisable as of December 31, 202512.4$20.24 5.43$77 
Schedule of Assumptions Used to Calculate Fair Value and the Weighted-Average Grant Date Fair Value of Stock Options Granted The following table summarizes the key assumptions used to calculate the fair value and the resulting weighted-average grant date fair value of stock options granted:
 Year Ended December 31,
Stock Options202520242023
Weighted average closing price of our common stock on grant date$12.75 $15.61 $21.21 
Risk-free interest rate
3.8% - 4.0%
3.6% - 4.4%
3.6% - 4.6%
Expected term (in years)6.026.026.02
Volatility
75.8% - 77.1%
77.2% - 77.4%
77.7% - 79.1%
Dividend yield—%—%—%
Weighted average fair value of stock options granted$8.84 $10.91 $14.81 
Year Ended December 31,
ESPP202520242023
Risk-free interest rate
3.5% - 4.4%
4.1% - 5.4%
4.3% - 5.4%
Expected term (in years)
0.5-2
0.5-2
0.5-2
Volatility
57.6% - 65.1%
59.0% - 70.0%
61.1% - 86.9%
Dividend yield—%—%—%