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Stock-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2024
Share-Based Payment Arrangement [Abstract]  
Summary of Stock-Based Compensation Expense
The following table reflects the components of stock-based compensation expense recognized in our Consolidated Statements of Operations (in millions):
Year Ended December 31,
202420232022
Research and development$38 $35 $33 
General and administrative38 38 32 
Total stock-based compensation$76 $73 $65 
Summary of Restricted Stock Units Activity The following table summarizes information regarding our RSUs for the year ended December 31, 2024:
Total RSUs
(in millions) 		Weighted
Average
Grant Date Fair Value Per Share
Nonvested at December 31, 20231.5$25.43 
RSUs granted2.0$15.55 
RSUs vested(1.1)$23.64 
RSUs forfeited or canceled(0.2)$18.36 
Nonvested at December 31, 20242.2$18.07 
Summary of Information Regarding Stock Options The following table summarizes information regarding our stock options for the year ended December 31, 2024:
Shares
Subject to
Outstanding
Options
(in millions) 		Weighted
Average
Exercise
Price Per
Share		Weighted
Average
Remaining
Contractual
Term (in years)		Aggregate
Intrinsic
Value
(in millions)
Outstanding at December 31, 202313.5$21.31 
Options granted2.8$15.61 
Options exercised(0.3)$11.45 
Options forfeited or canceled(0.5)$25.57 
Outstanding at December 31, 202415.5$20.31 6.61$19 
Options vested and expected to vest as of December 31, 202415.5$20.31 6.61$19 
Options exercisable as of December 31, 202411.3$20.47 5.90$19 
Schedule of Assumptions Used to Calculate Fair Value and the Weighted-Average Grant Date Fair Value of Stock Options Granted The following table summarizes the key assumptions used to calculate the fair value and the resulting weighted-average grant date fair value of stock options granted:
 Year Ended December 31,
Stock Options202420232022
Weighted average closing price of our common stock on grant date$15.61 $21.21 $30.37 
Risk-free interest rate
3.6% - 4.4%
3.6% - 4.6%
2.4% - 4.0%
Expected term (in years)6.026.026.02
Volatility
77.2% - 77.4%
77.7% - 79.1%
76.5% - 79.3%
Dividend yield—%—%—%
Weighted average fair value of stock options granted$10.91 $14.81 $20.75 
Year Ended December 31,
ESPP202420232022
Risk-free interest rate
4.1% - 5.4%
4.3% - 5.4%
1.6% - 4.7%
Expected term (in years)
0.5-2
0.5-2
0.5-2
Volatility
59.0% - 70.0%
61.1% - 86.9%
68.9% - 82.5%
Dividend yield—%—%—%