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Stock-Based Compensation - Assumptions used to Calculate Fair Value of Stock-Based Compensation (Details)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Expected term (in years) 10 years    
Dividend yield 0.00%    
Employee Stock Option      
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Risk-free interest rate, minimum 1.20% 1.66% 1.20%
Risk-free interest rate, maximum 3.10% 2.20% 2.45%
Volatility, minimum 58.70% 67.00% 67.00%
Volatility, maximum 75.50% 71.70% 77.80%
Dividend yield 0.00% 0.00% 0.00%
Employee stock purchase plan      
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Risk-free interest rate, minimum 2.11%    
Risk-free interest rate, maximum 2.63%    
Volatility, minimum 54.30%    
Volatility, maximum 65.50%    
Dividend yield 0.00%    
Minimum | Employee Stock Option      
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Expected term (in years) 5 years 1 month 28 days 5 years 11 months 12 days 6 years 3 months
Minimum | Employee stock purchase plan      
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Expected term (in years) 6 months    
Maximum | Employee Stock Option      
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Expected term (in years) 9 years 11 months 12 days 9 years 11 months 26 days 9 years 10 months 2 days
Maximum | Employee stock purchase plan      
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Expected term (in years) 2 years