Fair Value Measurements - Additional Information (Details) - BVF Partners L.P. - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
BVF Agreement
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Imputed effective rate of interest on unamortized portion of liability	20.60%	20.60%
Non-refundable payments received		$ 15,000,000	$ 15,000,000
BVF Agreement | Maximum
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Contingent payments upon achievement of certain clinical and regulatory milestones			73,000,000
Gilead Collaboration Agreement | Maximum
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Contingent payments upon achievement of certain clinical and regulatory milestones			$ 160,000,000