Fair Value Measurements - Additional Information (Details) - BVF Partners L.P. - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
BVF Agreement
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Non-refundable payments received	$ 15,000,000	$ 15,000,000
Imputed effective rate of interest on unamortized portion of liability	20.60%
BVF Agreement | Maximum
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Contingent payments upon achievement of certain clinical and regulatory milestones		73,000,000
Gilead Collaboration Agreement | Maximum
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Contingent payments upon achievement of certain clinical and regulatory milestones		$ 160,000,000