Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Purchase Agreement Gilead	Common Stock	Common Stock Purchase Agreement Gilead	Additional Paid-In Capital	Additional Paid-In Capital Purchase Agreement Gilead	Accumulated Deficit	Accumulated Other Comprehensive Income (Loss)
Balance at Dec. 31, 2020	$ 502,304		$ 6		$ 830,438		$ (328,184)	$ 44
Balance, shares at Dec. 31, 2020			63,691,901
Issuance of common stock		$ 220,296		$ 1		$ 220,295
Issuance of common stock, shares				5,650,000
Issuance of common stock upon exercise of stock options and vesting of restricted stock	1,885				1,885
Issuance of common stock upon exercise of stock options and vesting of restricted stock, shares			200,828
Vesting of early exercised stock options	183				183
Vesting of early exercised stock options, shares			54,039
Stock-based compensation	12,761				12,761
Other comprehensive loss	(46)							(46)
Net income (loss)	(72,593)						(72,593)
Balance at Mar. 31, 2021	664,790		$ 7		1,065,562		(400,777)	(2)
Balance, shares at Mar. 31, 2021			69,596,768
Balance at Dec. 31, 2020	502,304		$ 6		830,438		(328,184)	44
Balance, shares at Dec. 31, 2020			63,691,901
Net income (loss)	(226,538)
Balance at Sep. 30, 2021	542,607		$ 7		1,097,414		(554,722)	(92)
Balance, shares at Sep. 30, 2021			70,202,448
Balance at Mar. 31, 2021	664,790		$ 7		1,065,562		(400,777)	(2)
Balance, shares at Mar. 31, 2021			69,596,768
Issuance of common stock upon exercise of stock options and vesting of restricted stock	843				843
Issuance of common stock upon exercise of stock options and vesting of restricted stock, shares			269,369
Vesting of early exercised stock options	175				175
Vesting of early exercised stock options, shares			36,245
Issuance of common stock under Employee Stock Purchase Plan	1,394				1,394
Issuance of common stock under Employee Stock Purchase Plan, shares			140,408
Stock-based compensation	13,367				13,367
Other comprehensive loss	(44)							(44)
Net income (loss)	(75,970)						(75,970)
Balance at Jun. 30, 2021	604,555		$ 7		1,081,341		(476,747)	(46)
Balance, shares at Jun. 30, 2021			70,042,790
Issuance of common stock upon exercise of stock options and vesting of restricted stock	1,318				1,318
Issuance of common stock upon exercise of stock options and vesting of restricted stock, shares			125,182
Vesting of early exercised stock options	170				170
Vesting of early exercised stock options, shares			34,476
Stock-based compensation	14,585				14,585
Other comprehensive loss	(46)							(46)
Net income (loss)	(77,975)						(77,975)
Balance at Sep. 30, 2021	542,607		$ 7		1,097,414		(554,722)	(92)
Balance, shares at Sep. 30, 2021			70,202,448
Balance at Dec. 31, 2021	$ 841,450		$ 7		1,118,058		(275,354)	(1,261)
Balance, shares at Dec. 31, 2021	70,781,736		70,771,790
Issuance of common stock upon exercise of stock options and vesting of restricted stock	$ 9,928				9,928
Issuance of common stock upon exercise of stock options and vesting of restricted stock, shares			840,577
Vesting of early exercised stock options	52				52
Vesting of early exercised stock options, shares			9,946
Stock-based compensation	16,541				16,541
Other comprehensive loss	(3,399)							(3,399)
Net income (loss)	(67,993)						(67,993)
Balance at Mar. 31, 2022	796,579		$ 7		1,144,579		(343,347)	(4,660)
Balance, shares at Mar. 31, 2022			71,622,313
Balance at Dec. 31, 2021	$ 841,450		$ 7		1,118,058		(275,354)	(1,261)
Balance, shares at Dec. 31, 2021	70,781,736		70,771,790
Net income (loss)	$ (199,544)
Balance at Sep. 30, 2022	$ 698,701		$ 7		1,183,393		(474,898)	(9,801)
Balance, shares at Sep. 30, 2022	72,352,380		72,352,380
Balance at Mar. 31, 2022	$ 796,579		$ 7		1,144,579		(343,347)	(4,660)
Balance, shares at Mar. 31, 2022			71,622,313
Issuance of common stock upon exercise of stock options and vesting of restricted stock	2,050				2,050
Issuance of common stock upon exercise of stock options and vesting of restricted stock, shares			320,603
Issuance of common stock under Employee Stock Purchase Plan	2,296				2,296
Issuance of common stock under Employee Stock Purchase Plan, shares			142,557
Stock-based compensation	15,677				15,677
Other comprehensive loss	(2,584)							(2,584)
Net income (loss)	(66,632)						(66,632)
Balance at Jun. 30, 2022	747,386		$ 7		1,164,602		(409,979)	(7,244)
Balance, shares at Jun. 30, 2022			72,085,473
Issuance of common stock upon exercise of stock options and vesting of restricted stock	2,531				2,531
Issuance of common stock upon exercise of stock options and vesting of restricted stock, shares			266,907
Stock-based compensation	16,260				16,260
Other comprehensive loss	(2,557)							(2,557)
Net income (loss)	(64,919)						(64,919)
Balance at Sep. 30, 2022	$ 698,701		$ 7		$ 1,183,393		$ (474,898)	$ (9,801)
Balance, shares at Sep. 30, 2022	72,352,380		72,352,380